Coopers® Clostri 10

FOR ANIMAL USE ONLY

COOPERS® CLOSTRI 10
Reg. No. G4206 (Act 36/1947)
Clostridial vaccine for Cattle and Sheep.

INDICATIONS
A vaccine for the active immunisation of healthy cattle and sheep older than 3 months of age against:
Enterotoxaemia, haemorrhagic enteritis, blackleg, malignant oedema (gas gangrene), necrotic enteritis, lamb dysentery, infectious necrotic hepatitis (black disease), haemorrhagic enterotoxaemia (struck), pulpy kidney disease, bacillary haemoglobinuria, sudden death syndrome and tetanus.

COMPOSITION
Contains bacterin and toxoids of Clostridium spp. to meet the following potency values;

	Potency value/dose
C. chauvoei	Complies Ph. Eur. and CFR (USA)
C. haemolyticum	Complies CFR (USA)
C. septicum	≥ 2,5 IU
C. sordellii	≥1 IU
C. tetani	≥ 2,5 IU
C. novyi type B	≥ 3,5 IU
C. perfringens type A	≥ 0,5 IU α toxoid
C. perfringens type C	≥ 10 IU β toxoid
C. perfringens type D	≥ 5 IU ξ toxoid

Although Clostridium perfringens type B is not a component of the vaccine, immunity is provided against the beta- and epsilon toxins produced by Clostridium perfringens type B. This is due to the combination of C. perfringens type C (beta toxin) and type D (epsilon toxin) fractions.

STORAGE

• Store between 2 °C and 8 °C.
• Do not freeze.
• Protect from light.
• Shake well before use.

WARNINGS

• Withdrawal period: Do not slaughter animals for human consumption within 21 days of last administration.
• Vaccinate only healthy cattle and sheep over 3 months of age.
• Concurrent use of other vaccines is not recommended.
• Do not mix the vaccine with other veterinary medicinal products.
• As with all vaccines, occasional hypersensitivity reactions may occur. In such cases, appropriate treatment such as adrenaline and/or antihistamines should be administered without delay. Consult a veterinarian.
• As with all vaccines, absolute immunity cannot be guaranteed in all animals. It is, therefore, advisable to consult a veterinarian regarding additional control measures instead of relying on the vaccine alone.
• Usually no marked reaction follows vaccination although a transient swelling may appear at the site of inoculation, and some animals may show a moderate rise of temperature for one or two days.
• Dispose of any unused vaccine as well as all empty vaccine containers and vaccination equipment according to local waste disposal regulations at the end of each day’s operations, as under field conditions it may be difficult to avoid accidental contamination of the vaccine.
• KEEP OUT OF REACH OF CHILDREN, UNINFORMED PERSONS AND ANIMALS.
• Although this vaccine has been extensively tested under a large variety of conditions, failure thereof may ensue as a result of a wide range of reasons. If this is suspected, seek veterinary advice and notify the registration holder. 

PRECAUTIONS

• Only sterile needles and properly sterilised vaccinators should be used. In order to maintain proper hygiene, it is advisable to change to clean sterile needles as frequently as possible. 
• In case of long fleece, it is necessary to make sure that the needle has penetrated the skin before injecting the product.

DIRECTIONS FOR USE – USE ONLY AS DIRECTED
The bottle should be shaken well before doses are withdrawn.
Method of administration: Subcutaneous injection.

Dosage
Cattle and calves over 3 months of age
Primary vaccination: Two injections of 4 mℓ each with an interval of 4 to 6 weeks.
Revaccinate with a single dose.

Sheep and lambs over 3 months of age
Primary vaccination: Two injections of 2 mℓ each with an interval of 4 to 6 weeks.
Revaccinate with a single dose.

Administration

• Subcutaneous injection in loose skin, preferably on the side of the neck.
• After primary vaccination course, animals must receive booster injections at intervals of not more than 12 months. 
• In high risk areas where animals are likely to be exposed to exceptionally severe infection or high concentrations of botulism toxins in food, water or environment, vaccination every 4 to 6 months is necessary, especially for young animals with little or no previous vaccination history.
• The vaccine course should be completed at least 2 weeks before maximum immunity is required i.e. a period of risk or pregnancy.
• Previously sensitised cows/ewes should be injected at least 2 weeks prior to calving/ lambing as this will provide passive protection for several weeks via the colostrum.
• When animals under 3 months of age have been vaccinated it may be advisable to revaccinate at 4 to 6 months of age, especially in high risk conditions/areas. Vaccinate annually thereafter. Consult a veterinarian.

PRESENTATION
Polypropylene containers of 100 mℓ with synthetic rubbers stoppers and aluminium seals.
Each vial is packed as a single unit inside a carton box.

REGISTRATION HOLDER
Cooper Veterinary Products (Pty) Ltd.
20 Spartan Road
Spartan, 1619, RSA
Tel: +27 (0) 11 923 9300
Fax: +27 (0) 11 392 3158
www.coopersanimalhealth.co.za